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Operating procedure for milli Q water system

  • OBJECTIVE
  • To lay down the procedure for Operation of Milli Q water system, Make Millipore.
  • SCOPE
  •  This SOP shall provide the Operating procedure of Milli – Q water system of quality control department.
  • RESPONSIBILITY
  •  Officer/ Executive – Quality Control
  • ACCOUNTABILITY
  • Head QC/QA
  • PROCEDURE
  • OPERATION OF ELIX –10
  • Switch on Elix – 10 power supply button provided backside of the instrument.
  • Indicator green light glows and LCD Screen displays

ELIX 10

SR.NO-

  • Above information shall be displayed for few seconds and system goes in stand by mode.
  • System starts performing flushing and returns to normal stand by mode.
  • Press and hold for about 5 seconds operate / stand by button to switch in to operation mode.
  • In operation mode system collects water from source and starts purification.
  • The LCD screen while operation mode shows

PRES :            XXX       %TANK

RO Feed:        XXX        µ S

  • Note:  Do not operate the system with pressure less than 2.0 kg/cm2 (system starts alarm – red light blinks and LCD shows LOW PRES) , if required switch on the power of primary cartridge filter pump for required pressure.
  • Purified water generated from the ELIX –10 collected continuously in HDPE – 30 liters storage tank.
  • System stops/ starts automatically when HDPE TANK is full/empty.
  • Note:  Do not collect water from storage tank when ELIX –10 Screen shows less than 30  % tank full, allow the system to collect water minimum up to 60 % tank full condition.
  • Whenever required, Collect the water from HDPE storage tank for the purpose of dissolution / disintegration testing and their bath filling purpose only.
  • OPERATION OF GRADIENT A 10
  • Switch on GRADIENT A 10 power supply button provided backside of the instrument.
  • Indicator green light glows and LCD Screen displays

GRADIENT A 10                                  V 3.05

SR.NO°

for few seconds and starts in stand by mode.

  • Press and hold for about 5 seconds OPERATE / STAND BY button to switch in to operation mode.
  • Move the point of use trigger forward till the green bulb glowing starts to initiate the water purifying process.
  • When the bulb is glowing GRADIENT A 10 LCD screen shows the quality of water in terms of conductivity in µS at @25°C and TOC level in ppb.
  • Move the point of use trigger forward and collect the required quantity of water.
  • Close the point of use trigger backward after collecting water.
  • This water shall be used for all laboratory grade water (i.e. – for the purpose of HPLC analysis, column washing, glassware final rinsing, chemicals/ reagents preparation, final dilutions).
  • NOTE:
  1. Do not use the water if conductivity is more than 1.3 µ S and TOC level is more than 500 ppb.
  1.  Do not collect water when HDPE TANK is ≤ 30 % full. Allow the system to collect water minimum up to 60 % of tank full condition.
  2.  Replacing frequency of Cartridges of  ELIX –10 / GRADIENT A10 shall be half – yearly or if the system fails to produce the water of required quality ( conductivity – ≤ 1.3 µ S and TOC –  ≤ 500 ppb.
  3. Note the reading of conductivity & TOC ,twice in a day, preferably startup & end of the shift .
  • Forms and Records (Annexures)
  • Not Applicable
  • Distribution
  • Master copy –  Quality Assurance
  • Controlled copies- Quality Assurance, Production, Quality Control.engineering
  • History
    Date Revision Number Reason for Revision
    00 New SOP

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